Hi, it depends on what aspect of diabetes is your target. Are you looking to see the insulin-sensitizing or insulin secretion potential of your product, or its effect on any related complication? you could simply use muscle, liver or adipose cell lines to test the effect of the product on glucose uptake in the presence or absence of insulin and so on. You could also use pancreatic cell line to test insulin release. We have worked on these and also other complications of diabetes like the polyol pathway by studying the effect of our product on aldose reductase activity. In addition, we also study the transcriptional changes induced by our products in genes related to glucose metabolism.