There are so many changes including physiological,histological,biochemical and immunological changes associated with secondary TB. So what is the mechanism that leads to tumour of lung sometimes?
Recently, some authors have investigated the involvement of macrophages in the progression of TB lung cancer , here I leave the reference:
Tumour Biol. 2015
Macrophages are needed in the progression of tuberculosis into lung cancer.
Li J1, Pan Y, Zhang B, Chen Q.
regards...
Mycobacterium TB requires a higher oxygen concentration and has a preference toward the tissue with the highest partial pressures of oxygen, As the partial pressures of oxygen drops dramatically in the tumor tissue, the environment becomes less than optimal for the survival of this bacteria.
one explanation is that Mycobacterium TB causes chronic infection (chronic inflammation) which is one of predisposing factors for tumor formation.
EGFR mutations might contribute.
http://medicalxpress.com/news/2012-01-link-tb-gene-mutation-lung.html
http://journals.lww.com/jto/Fulltext/2012/02000/Association_between_Tumor_Epidermal_Growth_Factor.6.aspx
Regards,
Joachim
"Scar cancer of the lung" is a well-recognized entity and is usually adenoca that can begin in an area of "healed" Tb. The underlying mechanism is not certain but physical injury to adjacent "normal" lung and/or chronic inflammation would be reasonable hypotheses to explain the possible cause. michael newhouse.
My great thanks to all scientists who were generous in giving what they know about this problem.Mohemid
Solo conozco el " carcinoma de cicatriz" en tuberculosis ya curadas.
De acuerdo con los Drs Newhouse y Braenbtll.Saludos
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