I need to know how the prime-boost vaccines design for intracellular pathogens can generate different subsets of memory CD8 T cell. Vaccines for intracellular pathogens are too difficult because they need to create a specific memory CD8 T cell. Understanding this, we could change the concentration of the antigen, and the frequency between prime and boosting depending in the specific pathogen for improving currently vaccines and obtain new vaccines for intracellular pathogens.
Hello, I don't see your point. What do you mean by "different subsets of memory CD8 T cells"? TCM versus TRM?
Ok, there are TCM, there are TEM and quite recently we have learnt that there are also TRM (Resident Memory T cells). Many recent papers demonstrate that TRM are the best subset providing protective immunity in their tissue of residence, mainly in non-lymphoid tissues. The JI paper of Masopust that you commented suggests that multiple boosting (tertiary responses) increase the number of TEM (and probably TRM depending on the route of vaccination). Recent papers would also be in line with this idea. Therefore, the question is whether you would like to vaccinate to generate TCM, TEM or TRM?
You might find the article by Reed et al helpful: Reed, Orr, and Fox 2013 "Key roles of adjuvants in modern vaccines" Nature Medicine 19:1597-1608.
DNA vaccination generates T-cell response over antibodies. This is particularly true in primates.
Inulin is pretty good at Th1. http://www.ncbi.nlm.nih.gov/pubmed/7551236
Various adjuvants. I'd second what Randall Howard wrote. http://www.ncbi.nlm.nih.gov/pubmed/24309663
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