Please see our paper in the following link:

https://www.sciencedirect.com/science/article/abs/pii/S0039914019301638

The calculations of Analytics Eco-scale for evaluation of method greeness are revealed in section 3.12 of this paper.

Hi Roopali. I don't think you can find a online tool for calculating the greeness. Recently, this tool has been introduced for the evaluation of environmental effects of developed method on human health. I have a good experience in this field. If you persue my recent papers, you will find out how to calculate the greatness score. If you have any question, please let me know.

Hi Roopali the AMGS was made public on a website found here:

Glad that Jansen is thinking about using this now. AMGS Calculator: https://www.acsgcipr.org/amgs

Many others in academics and pharma have used this to help develop greener methods,

kind regards

Mike

Hi Roopali, the AMGS software is free and available as a spreadsheet as and easy to use

Link for the AMGS calculator https://www.acsgcipr.org/amgs/

If you have any doubt about using this sheet, you can use this article for a better understanding

https://doi.org/10.1016/j.microc.2021.106685

Also you can use AGREE tool that is a novel downloadable greenness assessment software. AGREE is based on GAC's twelve principles and guidelines. In AGREE, the final score is a fraction of one, ranging from 0 to 1. The automatically generated pictogram is divided into twelve sections, with the width of each section adjustable according to its importance. Each section has its own colour scheme, ranging from deep green (=1) to deep red (= 0). The overall score appears in the center of the circular pictogram. The AGREE tool was designed based on general guidelines, including inclusiveness, input flexibility, simplicity, and yield clarity.

You can obtain the tool via a specific link provided in AGREE article

(F. Pena-Pereira, W. Wojnowski, M. Tobiszewski, AGREE - Analytical GREEnness Metric Approach and Software, Anal. Chem. 92 (2020) 10076–10082. doi:10.1021/acs.analchem.0c01887.)

And to know how to apply it on real examples you can read these newly published papers:

( K.M. Kelani, E.S. Elzanfaly, A.S. Saad, M.K. Halim, M.B. El-Zeiny, Different greenness assessment perspectives for stability-indicating RP-HPLC method used for the assay of isoxsuprine hydrochloride and four nephrotoxic and hepatotoxic photothermal degradation products, Microchem. J. 171 (2021) 106826. doi: 10.1016/j.microc.2021.106826.) .

(M. Gamal, I.A. Naguib, D.S. Panda, F.F. Abdallah, Comparative study of four greenness assessment tools for selection of greenest analytical method for assay of hyoscine: N -butyl bromide, Anal. Methods. 13 (2021) 369–380. doi:10.1039/d0ay02169e) .