I am trying to understand Emax model for calculation of EC50 from plasma drug concentration against time.
I am trying to google it but unable to find what i want. Every where they have used conc vs effect for calcylation .
How do i calculate effect from the data i have.
Try this links:
http://accp1.org/pharmacometrics/pkpdcourse2006/lec1.htm
The link to the Handbook provides an extensive explanation of the subject. Suggested search term: PHARMACOKINETICS.
Generally, dose response may be modeled as:
Y = min + (max - min) / [1 + (X / EC50)Hill coefficient]
See also:
http://www.merckvetmanual.com/mvm/pharmacology/pharmacology_introduction/drug_action_and_pharmacodynamics.html#v3329205?qt=&sc=&alt=
http://accp1.org/pharmacometrics/pkpdcourse2006/lec1.htm
https://books.google.co.th/books?id=eYJXj59Cg_UC&pg=PA1139&lpg=PA1139&dq=Emax+model+ec50&source=bl&ots=77FdhxNMjz&sig=twW-JWlV9OEQY2Txttd26pk_kxg&hl=en&sa=X&ei=q6pvVcqTEcLIuAStzoFA&ved=0CDgQ6AEwBQ#v=onepage&q=Emax%20model%20ec50&f=false
- Badges
- Science topic
- Similar topics
- Chemistry
- Pharmacology
- Pharmaceuticals
- Drugs