I have found it in a rat colon. May be a polyp or an adenoma?. Thanks
Just a few questions for you to see if I can help.... Is this supposed to be a cross section of the colon or did you just inflate it with formalin and lay it in the cassette? I'm struggling to see where the natural borders are and orientating myself - where is the normal colonic mucosa, etc? What did this look like, grossly? Were there any clinical signs in this rat? Also... any chance this is a male rat?
It is a transversal cross section of a formalin-fixed colon of a male rat. Colon is ouside of the picture, at the botton. Colon was normal.
Thank you Miranda
I think you may have picked up a portion of a seminal vesicle (especially if this is a separate piece from the normal colon, which you said is at the bottom of the slide and out of the images). While the magnification is pretty low, I don't see goblet cells in the epithelial component and the organization of the epithelium doesn't look quite colonic to me. There also seems to be some bright pink secretory material in the interior of the spaces. The connective tissue surrounding the structure also doesn't look like the typical two-layered muscularis of the GI tract. A colonic polyp or adenoma would most likely be present protruding from the mucosal surface and into the lumen of the colon and will have a very similar appearance to the normal colonic mucosa (with goblet cells).
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