Can anybody explain what is the methodology for coating of chitosan nano particles with pH responsive eudragit polymers?

08 August 2013 1 8K Report

Coating of ionic gelation nano particles.

There are carboxylic, pH-responsive Eudragit polymers (copolymers of alkyl methacrylates with acrylic or methacrylic acid). They may spontaneously adsorb on chitosan particles from aqueous solutions of low ionic strength at weakly alkaline pH. To separate the polymer from nanoparticles you may need ultrafiltration membrane. Further, if you wish chemical attachment, water-soluble carbodiimide for covalent linking of Eudragit to amino groups of chitosan may help. Check the literature for acylation of chitosan using this chemistry to find out detailed protocol. In case of success you may be able to precipitate the conjugate at lower pH, where Eudragit makes the particles hydrophobic , and to re-suspend them at higher pH.

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