Can anticancer drugs be effective against wounds? and can anti-inflamatory drugs be effective against early stage cancers?

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Comparison of tissue to serum MS data?

Hello, So I have mouse brain tissue MS data from one of my predecessors and I have human serum data from the hospital that I collaborate with. We are trying to find markers for the diagnosis of...

11 July 2024 8,484 0 View

Does anyone know any C++ implementation of Kolmogorov-Arnold network other than mine?

Mine is sitting here: http://openkan.org/DLpiecewiseCPP.html I wish to see someone else's.

06 July 2024 9,974 1 View

Music Therapy used in several colleges.Which one that are great?

I'd trying the several countries with several religions on young and older. what are which books so far. Sound Medicine, Music Medicine on many religions working now.

18 June 2024 1,907 1 View

What is the sampling rate of the Polar H10?

I have read a few papers that have indicated that the sampling rate of the Polar h10 is 1000 Hz. 1) Navalta et al., Heart rate processing algorithms and exercise duration on reliability and...

10 June 2024 4,744 1 View

How come I cannot visualize linear DNA, open circular DNA, and Supercoiled DNA on my DNA nicking assay?

I have already tried different combinations of optimized DNA Nicking Assay protocols. The plasmid DNA that I use is puc19 from a transformed E.coli. Every single time I perform my Assay, I always...

30 May 2024 1,457 2 View

Culturing muscle cells in DMEM?

Hello everyone, I would like to culture muscle cells, specially Human Umbilical Aortic Smooth Muscle Cells (HUASMCs) in DMEM. There are various papers out there where this has been done, however,...

28 May 2024 1,398 0 View

What are the drivers of wetland degradation specifically in western Uganda and how does it affect the livelihood of peeople?

wetland degradation; over exploitation of wetland lands /swamps. Drivers; causes/factors leading to

25 May 2024 3,382 1 View

What method is best for calculating confidence intervals for sensitivity and specificity?

I've used the basic formula : 95% confidence interval = sensitivity +/− 1.96 (SE sensitivity) Where SE sensitivity = square root [sensitivity – (1-sensitivity)]/n sensitivity) 95% confidence...

21 May 2024 2,227 1 View

Issue with DAPI staining on brain (dark spot in middle)?

Hi all, I have a question regarding something odd I'm seeing with DAPI on tissue. I'm trying to isolate the issue to prevent it in the future. I have sagittal brain sections on slides. For some...

15 May 2024 9,194 2 View

Housekeeping protein for serum?

As the title states, I am looking for a housekeeping protein for serum (for Western blots). This research is in the context of pregnancy so it has to take into account normal vs diseased (e.g....

15 May 2024 9,219 0 View

Is changing the medium during the experiment overestimate the results?

I am experimenting with cancer and non-cancer cells in a 12-well plate for 4 days with a seeding density 1*10^4/well, however, I noticed that the control group growth rate slows down on D3. Should...

07 August 2024 2,283 2 View

Which solvent is better to dissolve with secondary metabolites extracted from fungi?

I work on MCF7 cell cell for anticaner purpose and I wa to do drug preperation the drug ( secondary metabolites extracted from Aspergillus) My question which solvent is better with these secodary...

03 August 2024 4,725 2 View

Can i quantify a nanoparticle encapsulated in cell culture medium by hplc?

Hello, if you made a transwell assay where you incubate the cells with a nanoparticle-encapsulated drug and considering that in the oposite compartment you'll have both the free and encapsulte...

03 August 2024 2,730 1 View

How to maintain the drug concentration in cell culture study for long term?

I am working in the filed of long acting drugs with Nano formulation. I want to study the efficacy of my formulation in 2D cell cultures while this required media change on every two days. In such...

24 July 2024 8,696 0 View

How can I determine if a drug binds to a ribosome using a Cryo-EM map?

Hello, I am searching for the binding position of a drug in a ribosome, based on previous work indicating it binds there. The resolution of the ribosome-drug Cryo-EM map is around 2.5 Å. I've been...

19 July 2024 2,155 0 View

How to calculate percentage cumulative drug release?

How to calculate percentage cumulative drug release when, Total volume of dissolution media = 250ml Added formulation was equivalent to 10mg of drug Sample withdrawn = 1ml each time Sink condition...

15 July 2024 4,192 1 View

MTT assay - 6 well plate?

Hi, In the 6 well plate, when I am seeding the cells. Do I add 1ml of complete media to one of the wells for the control at this stage or do I wait unit I am treating the plates to do that? Also...

13 July 2024 9,783 1 View

How to convince decision makers to adjust the legislation to allow opening of drug consumption rooms?

In my country, there is a lot of public outcry in relation to the presence of drug injection and related behaviors in public. Hence at least the bigger cities would probably benefit from the...

08 July 2024 8,903 1 View

Is the use of microcrystalline cellulose MCC 102 in direct compression technology justified, given the low flowability of this excipient?

Hello everyone reading this topic! It is well known that microcrystalline cellulose 102 is recommended for use in direct compression technology, however, like other grades, it has poor flowability...

08 July 2024 2,807 0 View

What are the trending topic to writ e a review article on it?

The topic should relate to pharmacy ,drug, methos of drug discovery, or any other topic but related to dug or pharmaceutical field

02 July 2024 4,031 3 View