Compounds with molecular mass lower than aout 6000 Da are not able to eleicit the immunoresponse. If you would like to raise antibodies towards your 318.49-mass compound you need to couple it to a carrier (usually a protein)

thank you very much for this response. great help

any literature i can use to help me achieve this goal of increasing the molecular mass?

thanks in advance

Please have a look in the book "Bioconjugate Techniques" authored by Greg T. Hermanson. There you can find the basics and most of the major protocols.