Hi Renuka,

Yes, we can use  zebra fish embryos for this study. Zebrafish have been used for

antiangiogenic drug research and development because they can be a

useful and cheap tool to investigate angiogenesis in a complete verte-

brate system. You can refer those papers.

1.https://www.researchgate.net/publication/264745868_YLT192_a_Novel_Orally_Active_Bioavailable_Inhibitor_of_VEGFR2_Signaling_with_Potent_Antiangiogenic_Activity_and_Antitumor_Efficacy_in_Preclinical_Models

2. SKLB1002, a novel potent inhibitor of VEGF receptor 2 signaling, inhibits angiogenesis and tumor growth in vivo. Clin Cancer Res July 1, 2011 17; 4439

Article YLT192, a Novel, Orally Active Bioavailable Inhibitor of VEG...

 Here is a very good protocol  book about that