Researchers usually used irradiation (such as x-ray) to induce cancer cell apoptosis to prepare available antigens for DC to uptake that present the antigen to T cells. Can other apoptotic methods like anti-fas on cancer be used as an alternative way in terms of adoptive immunology?
Most cancer cells are resistant to CD95-mediated apoptosis that's why it can not be used systemically for cancer therapy. Likewise, it has plenty of side effects due to apoptosis induction in hepatocytes. In addition, a lot of cancer cells carry dominant mutations in CD95. So my suggestion for you to use targeting IAP-family members like XIAP, cIAP1, Survivin, or Apollon that can induce apoptosis in cancer cell lines in culture or sensitize cells to cytotoxic anticancer drugs.
Here's an article that might help you https://doi.org/10.1155/2014/150845
Most cancer cells are resistant to CD95-mediated apoptosis that's why it can not be used systemically for cancer therapy. Likewise, it has plenty of side effects due to apoptosis induction in hepatocytes. In addition, a lot of cancer cells carry dominant mutations in CD95. So my suggestion for you to use targeting IAP-family members like XIAP, cIAP1, Survivin, or Apollon that can induce apoptosis in cancer cell lines in culture or sensitize cells to cytotoxic anticancer drugs.
Here's an article that might help you https://doi.org/10.1155/2014/150845
Walid Hassene Hamri Thanks a lot for your answer. It is very informative and useful.
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