We are planning to increase intestinal permeability of a BCS class III drug using an ion pair approach. Can the ion pair complex be incorporated in the carriers like nanoparticles, or can it be freeze dried? Will the properties of the drug ion complex be retained in the freeze dried powder?
For class III of high solubility and low permeability drugs, ion pair complex can be incorporated, I guiss, yes, but, it might retard permeability as well.
I think it's important to find an answer by experimental investigations.
For the question, about the effect of freeze drying on the properties of drug ion complex.
If water molecules constitute important linking between drug molecules from one side and nanoparticle from the other side, it will be affected, mostly, otherwise, there will be less effects
- Badges
- Science topic
- Similar topics
- Physical Sciences
- Materials Science
- Materials Chemistry
- Polymer Chemistry