Is absorption of suspension/partially soluble drug less than a complete solution when administered i.p to rats? Will complete solution have more therapeutic efficacy than suspension when given i.p?
Intraperitoneal (i.p.) route of administration is used during the early stages of drug discovery to mainly avoid the intestinal barrier. Though it is possible to dose suspensions of test compounds by i.p. route, solutions are generally preferred due to the limited fluid supply to the peritoneal cavity which may help solubilize particles in the suspension. Preparing the test compounds in a vehicle containing solubilizing agent, suspending agent and/or surfactant may help. Please note that the test compounds dosed by i.p. route will primarily end up in the portal vein and is thus subject to hepatic first-pass metabolism. Hope this helps with your work.
Intraperitoneal (i.p.) route of administration is used during the early stages of drug discovery to mainly avoid the intestinal barrier. Though it is possible to dose suspensions of test compounds by i.p. route, solutions are generally preferred due to the limited fluid supply to the peritoneal cavity which may help solubilize particles in the suspension. Preparing the test compounds in a vehicle containing solubilizing agent, suspending agent and/or surfactant may help. Please note that the test compounds dosed by i.p. route will primarily end up in the portal vein and is thus subject to hepatic first-pass metabolism. Hope this helps with your work.
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