Can a particular protein dephosphorylated ( at the same kind of residue for example pTyrosine) by two different phosphatases in the same cell type?

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Yasuhiro Nishida

Do you mean whether multiple protein phosphatases can dephosphorylate for a particular phosphorylated residue of a protein in a certain cell?

It often happens. Remember MAPK phosphatases (MKPs/DUSPs) as an example.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139386/

https://www.jimmunol.org/content/jimmunol/177/11/7497.full.pdf

Amit Kumar

Thank you @Yasuhiro Nishida for your response. You got my question right.