While simulating fluids using CFD tools on 2D / planar mesh and 3D / volume mesh the flow will differ according to the cross-section obviously. In case of a flow mixing simulation, if the cross-section of both channel is rectangle a planar mesh solution gives similar result to a 3D mesh, whereas if the channel is of any other cross-section the flow physics shall vary. 

Attachments show analysis result of 2D and 3D mesh of a flow mixing with similar boundary conditions and meshing setup.

What is the criteria for choosing in between 2D and 3D mesh?

Do the analyses which used the 2D mesh strictly adhere to itself rather than a general setup?

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