The concept of calcium ion fatigue and muscle fatigue, in general, can be complex and multifactorial. While the involvement of calcium ions in muscle contraction and relaxation is well established, the exact mechanisms underlying muscle fatigue are still an area of active research. I'll try to provide some insights into the topic:

It is important to note that muscle fatigue is a complex phenomenon influenced by various factors, including metabolic processes, energy depletion, accumulation of metabolites (e.g., lactate), neural factors, and others. The interplay between these factors and the specific mechanisms involved in muscle fatigue are still being investigated.

To gain a more comprehensive understanding of muscle fatigue and the role of calcium ions, it is recommended to refer to scientific literature and research papers in the field of muscle physiology and exercise science. These studies provide detailed insights into the mechanisms of muscle fatigue and the role of calcium ions in muscle function and fatigue.

Hello! Thank you so much for the reply, it helps alot, but I do have a comment.

I read a paper thats showed after training fibers experienced prolonged depolarization after eccentric contractions due to the activation of Sodium selective stretch activated ion channels . The skeletal muscles of rats showed increased permeability of sodium by 70% in 1-2 hr after initial exposure to stretching caused by exercise.

This excessive release of sodium ions reduced the release of calcium ions which reduced the muscles ability to contract in exercise as well.

So I guess the research is a little all over the place and since I heard these reseachers say that eccentric contractions are due to calcium ion influx in such absolutes, would you say it's too early to arise to a conclusion like that?