The venom contains MP1 molecule.
MP1 molecule and lipid membrane.
The potential of MP1 molecule as cancer drug.
Combination therapies.
Hello,
It is interesting but before going for combination therapy, the exact mechanism by which this venom can kill the cancer cells should be definde. Most of the natrual subestances with anti cancer properties work through Apoptosis! Also it should be investigated that this effect is in in vivo model as well as cell line! Then it can enter to the combination therapy studies.
Good Luck!
Hello Abdallah,
The anticancer of the molecule investigated coould attribute a high index of selectivity SI, it's imortant to continue the work!
But I would ask you about cell cancer used, and normal cell used?
Hello,
It is interesting but before going for combination therapy, the exact mechanism by which this venom can kill the cancer cells should be definde. Most of the natrual subestances with anti cancer properties work through Apoptosis! Also it should be investigated that this effect is in in vivo model as well as cell line! Then it can enter to the combination therapy studies.
Good Luck!
Ya its very true Polybia-MP1 (MP1 extracted from the venom of Brazilian wasp Polybia paulista) have anticancer potential. It used to target leukemic T lymphocytes (25 μM, high level of phospholipid) by pore forming activity as compared to normal lymphocytes (high level of cholesterol and sphingomyelin). MP1 was used to inhibit multidrug-resistant leukemic cells, bladder and prostate cancer without any cytotoxic and hemolytic activities.
Firstly, a reference needed to support the claim of the questioner..
@Joe Graymer, read the above comment of @Bhupender Sharma or search the topic.
Regards.
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