So it is a well known fact that boron containing catalysts including boric acid are perfect choices for amide formation. however, my question is if anyone knows whether boric acid would still be useful if i wanna synthesise some amide in the aqueous media.
Sorry but because you did this synthesis before, I want to ask you something. As you know this synthesis we have to use xylene or toluene as solvent inorder to add dean stark apparatus that helps to remove water trases. But my question is what if toluene family doesnt dissolve my compound do you have any suggestion?
With respect to your question no you cant because this reaction suppose to be done with anhydrous condition.
I've only had success using the Dean-stark approach of distilling off the water that is formed. You could start with a water solution, but you would need to add toluene or xylene adn completely remove the water with the dean stark before the reaction would really get going.
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