Hi, I am building a mechanistic model of toxico- pharmacokinetics that includes first pass hepatic elimination. I cannot find a reference for the blood volume of the hepatic sinusoids (with Space of Disse) preferably in humans. I have found many papers that have flow rates none from which sinusoid volume can be calculated. There are several papers that have volumes for the large vessels. In that the liver is an important blood reservoir, the sinusoid volume must be quite variable. In a normal healthy adult, can you please give me references or nonpublished information of what has been measured to be or assumed to be, or calculated to be the mean blood volume of the hepatic sinusoids? Thank you in advance.
It is the intriguing question you asked here!
The total sinusoidal volume is approximately 40-50% of that of the liver, depending from the functional state of the latter and the organism as a whole (after quick jogging, one feels a colicki pain in the right hypochondrium - it is the liver contracts decreasing the volume of its sinusoids and delivering into the circulation up to 1 L of blood).
However, I have not met any precise data about the sinusoidal volume either in human, or in experimental animals anywhere yet, but this should not mean that they absent at all.
Sincerely,
Andrey Borodach
Hepatic blood volume in anaesthetized normel pig is about 25% (Munk OL, Bass L, Roelsgaard K, Bender D, Hansen SB, Keiding S. Liver kinetics of glucose analogs measured in pigs by PET: Importance of dual-input blood sampling. J Nucl Med 2001;42:795-801). We have data from on-going studies in pigs and healthy human subjects that confirm these results.
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