Transfusion related acute lung injury (TRALI) is a major cause of transfusion related death. Within 6-72 hours of transfusions of whole blood, packed red cells, fresh frozen plasma or platelets TRALI can develop. What could the measure/measures that might help in preventing the development of TRALI?
It could be reduced by fractionation of by that is transfusion of blood products required instead of whole blood.
Traly (transfusion Related Acute Lung Injury) can cause by trapping leukocytes and anti-leucocytes antibodies complex in alviolar spaces of lung , so leikoreduced blood components are helpful to avoid the situation
The UK had some success with reducing TRALI in infants who needed plasma by only using plasma from male donors for young patients.
Thanks Emmanuel Ifeanyi Obeagu, Dharmesh Chandra Sharma, Gayle Haider for your remarkable comments.
As mentioned leucodepletion, careful sourcing (male donors who have never been transfused) but also careful use of plasma - in the UK there are evidence based indication codes that are frequently ignored!
Leuko-reduced or leuko-depleted blood or blood components are helpful in solving the problem