Who have problems with homology modelling in Schrodinger Suite?
Sequence query gives error 400 or running without ending.
"Could not access NCBI to expand hits
Blast Error: HTTP Error 400: Bad Request"
400 means you are sending the request the server is unable to understand. Without looking into the request, or source code at least, there is no possibility to tell what goes wrong. It may be GET vs POST, HTTP vs HTTPS, misnamed/missing parameters, no login and lots of other things. Use some tool like Postman to make a valid HTTP request first. This may help you to understand what are you missing or doing wrong.
The server may have anti-DOS features like requirement to login, mandatory headers or similar. If they do not want a bot working with they site, it is probably better not to attempt without permission.
You should register for a NCBI API key:
https://ncbiinsights.ncbi.nlm.nih.gov/2017/11/02/new-api-keys-for-the-e-utilities/
That allows you more requests in time.
Problem was solved with following steps:
- updated API key for NCBI resources
- use of VPN (special "thanks" to Russian Roskomnadzor)
- update to Schrodinger 2020-2 version.
Thanks to all for assistance and advices
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