Bilirubin metabolism pathway in Cynomolgus monkey?

03 March 2016 0 8K Report

In human UGT1A1 seems to be the only relevant enzyme to glucuronidate unconjugated bilirubin into excreted forms (mono- and diglucuronides). Is the pathway the same for Cynomolgus monkey (Macaca fascicularis) in vivo? In case UGT1A1 is potently inhibited are there any other potential enzymes to glucuronidate/metabolise unconjugated bilirubin in Cynomolgus monkey? Any reference would be highly appreciated.

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