What is the best way for synthesis of 2',4-dihydroxychalcone?

I'm trying to synthesize 2',4-dihydroxychalcone using 2-hydroxyacetophenone and 4-hydroxybenzaldehyde. I've done several sythesis but all I get was some kind of oil and no precipitate of product...

03 April 2019 6,167 4 View

Can you use a t-test instead of an ANOVA in a multi-factorial design if you're interested in only one comparison?

25 February 2019 9,243 4 View

Does HRV-3C protease cleave TEV cleavage site?

I have heard some rumors that the HRV-3C protease can recognize and cleave ENLYFQG peptide, which is a consensus sequence cleaved by the TEV protease. Can anyone confirm or suggest some literature...

23 July 2018 1,321 4 View

Are there any wide-spectrum kinase inhibitors?

I wanted to analyze the phosphorylation of a certain mammalian protein. It is a standard procedure to add phosphatase inhibitors to extraction buffers to block the process of dephopshorylation....

12 March 2018 8,978 4 View

What book/article would be a good introduction into artificial neural networks?

Hi, I'd like to learn more about artificial neural networks, specifically pattern recognition algorithms. Unfortunately, I don't have much of a background in mathematics, so I'm looking for...

26 December 2017 4,850 2 View

What is the resolution of ion-exchange chromatography?

Dear all, I would like to ask what is the maximal achievable resolution of ion exchange chromatography in the matter of pI values. In particular I am wondering whether I will be able to separate...

11 October 2016 5,605 3 View

Software for load path optimized structural design of fiber reinforced materials?

Which software would be most suitable for carrying out a load path analysis of an existing part, such as an aircraft wing structure, and subsequently doing a topology optimization of that design...

09 August 2016 874 1 View

What are the best 3 different reporter proteins as fusion partners for structural studies?

07 July 2016 5,040 2 View

Which one of databases do you recommend to explore validated targets for miRNA categorized by disease/metabolic disorder?

24 November 2014 8,772 2 View

Can someone provide me with some advice on using BS3 crosslinker and DTT buffer?

I would like to perform a crosslinking experiment using BS3 crosslinker. My protein has 3 cysteines, but no S-S bridge, so I have to keep my protein in buffer with 5mM DTT. Can I perform the...

16 July 2013 9,690 9 View

flexibility of polymers chain

effect of double bond on the flexibility of polymers

07 April 2021 0 0 View

Formulation of polymer color flakes

I am writing to request some information for making polymer color flakes. I would appreciate the help.

17 March 2021 0 0 View

Binary Logistic Generalized Linear Mixed model in SPSS. Is it doable?

I want to analyses the proportion of swimming sperm of three species of fish in two salinities. To analyse the proportion of swimming sperm in a Generalized Linear Model, I would use a Binary...

03 March 2021 2,297 3 View

What is the most Operating System (OS) which can be INSTALL on Tiny hard devices like Raspberry Pi (RPi) hardware ?

I'm targeting to deploy a mesh network and manually configure MANET routing protocols. I'm preparing scenarios, architectures, and hard devices needed to do that. Are there some step-by-step...

03 March 2021 1,931 5 View

Can we classify HV and LV lines based on line length?

I have dataset which shows the length of power lines. I need to classify the lines based on the line length. Is there a rule to classify the High voltage (HV) and low voltage (LV) lines based on...

03 March 2021 4,116 4 View

How to analyze a particular region of my simulation box in GROMACS?

Hi, I am using GROMACS 5.1.4 to simulate water in contact with a surface. I am only interested to calculate some properties of water near the surface. Let's say at a distance of x nm from the...

03 March 2021 9,989 2 View

Polymer composites suddenly solidifies?

I am making polymer composite by solvent mixing method. When I am trying to add filler solution in polymer solution it quickly get solidified. How to make them then uinform? It doesn't give time...

03 March 2021 7,540 4 View

What techniques can I use to determine the miscibility of polymer blends?

The term miscibility refers to the single-phase state in thermodynamics. I do not mean the compatibility of different components. To determine the miscibility I know several techniques such as...

03 March 2021 4,107 4 View

Is there a classification scheme for rock cavities or caverns with respect to their size and shape?

The range of forms and sizes of cavities in rock is very big. Is there a classification scheme for rock cavities regarding their size and shape?

02 March 2021 4,511 3 View

Do I need to do linear regression before running mediation analysis using PROCESS MACRO by Hayes ?

I just wanted to check if I need to run a linear regression separately if I am using PROCESS MACRO to run mediation analysis. Thank you.

02 March 2021 4,359 3 View