Hi, which tagged nanoparticle 1-2nm in diameter is best for an in vivo delivery towards Macrophage and CD4+ T cell-protein-membrane attachments? Meaning which nanoparticle is most biocompatible, potent, affective, stable etc. for this task?
After some preliminary research I have narrowed this down to gold or iron-oxide with gold seeming better for this application since iron-oxide seems to be more applicable to imaging, opinions appreciated?
Thanks:)
What is the purpose of your study?
Why are you targeting 1-2 nm is there any special reason?
Hello Prashant and thank you for the reply, I had found this answer in literature:)
Sound’s great.
We have also published some data last year related to your question using ZnO nanoparticles, If you are interested you can read it here:
https://www.researchgate.net/publication/310838911_Generation_of_protective_immunity_against_Orientia_tsutsugamushi_infection_by_immunization_with_a_zinc_oxide_nanoparticle_combined_with_ScaA_antigen
All the best
Dear Joel Subach,
As far as I know, ZnO is not bioinert, but it is Biocompatible.
Few reports have shown toxicity, mostly concentration and size dependent.
The purpose of the study is most important, if you want to target immune cells or immune response, ZnO can be a better option.
That is the reason why I asked you about the size you are targeting, as far as I understand tiny nanoparticles can escape endocytosis and would not be suitable for Antigen presentation and can be more toxic. Please check the following paper:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922601/pdf/1477-3155-12-5.pdf
Hope this helps.
All the best
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