I want to work on diabetes associated cognition impairments, but at what time behavioral experiments will be started after the development of diabetes i.e. 4, 6 or 8 weeks after successful diabetes.
Best regards
How do you define successfully developing diabetes?
Depending on the severity of diabetes, their life-span without some intervention will greatly diminish.
What question are you trying answer by your study? Relationship of duration of hyperglycemia with cognitive impairment? Search through the literature to find what is already known in rats and go from there.
In case of humans, a good deal of information already exists. For example:
Relationships Between Hyperglycemia and Cognitive Performance Among Adults With Type 1 and Type 2 Diabetes
http://care.diabetesjournals.org/content/28/1/71.full
First I highly agree with dr.Tausif, also, the following paper may be helpful.
Regards
Article The Effects of Type 1 Diabetes on Cognitive Performance A me...
Article Cognition in the Early Stage of Type 2 Diabetes
The study performed by Cox DJ et al (2005) titled "Relationships between hyperglycemia and cognitive performance among adults with type 1 and type 2 diabetes" can help you.
I really appreciate for all the comments from all the persons and sincere thanks to all of you sending some good research papers to kick off my experiments.
Best regards
Effects of Duration of Diabetes on Behavioural and Cognitive Parameters in Streptozotocin-Induced Juvenile Diabetic Rats
Ravishankar Rajashree,1 Sanjiva D Kholkute,2 and Shivaprasad S Goudar1
Author information ► Article notes ► Copyright and License information ►
Abstract
Background:
Diabetic encephalopathy is a recently recognised complication of early-onset type 1 diabetes in children. The abnormalities underlying diabetic encephalopathy are complex and poorly understood, and the impact of disease duration on behavioural and cognitive parameters also remains unclear. Hence, the present study was conducted to determine the effects of different durations of hyperglycaemia on behavioural and cognitive parameters in young streptozotocin-induced diabetic rats.
Methods:
Diabetes was induced in young, weaned, age-matched rat pups by streptozotocin injection (50 mg/kg body weight, intraperitoneally). Diabetic status was confirmed on post-natal day 30. The rats were tested in the elevated plus maze 10 and 2o days after diabetes induction.
Results:
Diabetic rats had significantly impaired behavioural and cognitive functions compared with age-matched controls. Increased anxiety levels and cognitive deficits were observed in rats that had been diabetic for 20 days compared with their 10-day counterparts.
Conclusion:
It is essential to diagnose and treat early-onset type 1 diabetes in young children to prevent irreversible cognitive dysfunction.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328933/
Effect of Resveratrol on Behavioral Performance of Streptozotocin-induced Diabetic Mice inAnxiety Tests
Juan P. Damián,1,2 Victoria Acosta,1 Maira Da Cuña,1 Isara Ramírez,1 Natalia Oddone,1 Ana Zambrana,1 Verónica Bervejillo,1 and Juan C. Benech1
Abstract
The aim of this study was to evaluate with anxiety tests the effect of resveratrol (RSV) on streptozotocin (STZ)-induced diabetic mouse behavioral performance at the second and fourth week of treatment. Confirmed diabetic mice (>250 mg/dl of glucose in blood after STZ injection) were treated with RSV (RDM, n=12) or control treated (DM, n=12) for 4 weeks. DM and RDM were tested in the Open Field Test (OFT) and Elevated Plus Maze (EPM). In the second week of RSV treatment, a higher grooming frequency (P
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