Please anyone explain inorganic form is highly toxic than organic form ?
Arsenic toxicity inactivates 200 enzymes involved in cellular energy pathways and DNA replication and repair.It is substituted for phosphate in high energy compounds such as ATP.
Dear Dr Surbhi Lilhare . Excretion of arsenic is dependant on valence state and form. Arsenite the (trivalent form) has a slower excretion rate compared to arsenate the (pentavalent form) and organic arsenic, which may contribute to arsenite's increased toxicity compared to arsenate and organic arsenic. See the link: https://www.ncbi.nlm.nih.gov/books/NBK541125/
Arsenites (As3+ or trivalent, arsenic trioxide) are 5–10 times more toxic than arsenates (As5+ or pentavalent) due to their higher solubility. See the useful link: https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/arsenites
Arsenate is toxic to bacteria because, as an analog of phosphate, it is transported by bacterial phosphate transport systems and interferes intracellularly with production of phosphorylated intermediates. Arsenylated sugars, for example, are unstable and spontaneously hydrolyze. See the useful link : https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/arsenate
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