I agree that the choice of self-medication might have some genetic relationship to that of the parents because what works for them might also work for the offspring, but the reason for needing self-medication has a lot more to do with overwhelming experiences in very early childhood and the lack of models for how to cope with them. I have a sense that something very complex is being reduced to an overly simplistic model. Also where does nicotine exposure come in, both prenatally (passive and active) and growing up. Are you counting nicotine use in the model?
Article Parental Separation and Offspring Alcohol Involvement: Findi...
https://www.researchgate.net/publication/265692670_Adverse_Events_in_Children_Predictors_of_Adult_Physical_and_Mental_Conditions
Article Adverse Events in Children: Predictors of Adult Physical and...
Definitely not, but I do know about ACE. Adverse childhood experiences are usually tramatic and influenced by adults. There are a number of studies that are looking into ACE and I suggest you find those and read them.
All the best,
Louise
Since you are not one of the PIs could you forward this question to someone who can answer it?
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