I check the mutation frequency of several tumor driver genes on COSMIC
http://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=BRCA2
For instance, there are two data.
Total number of unique samples: 42439
Unique samples with mutations: 797
I would like to ask whether these mutations are heterozygous or loss of heterozygosity or sum of both cases. I think it might make a great difference for tumor repressor genes.
Dear Chan Qin,
You can predict whether a hetero or homozygous mutation of a particular variant by tracking its original article. From the databases, it is hard to say that.
I'd suggest you to go to omim:
https://www.omim.org/entry/600185?search=brca2&highlight=brca2
Kindly have a look,
You can use these two links
http://exac.broadinstitute.org/
http://www.hgmd.cf.ac.uk/ac/index.php
Best of luck
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