Are there tools for simulating Omni-C libraries?

25 April 2022 0 4K Report

Hi everyone!

I would like to simulate Omni-C data for some genomes and I only can find tools that simulate Hi-C (e.g., sim3C, Free-HiC. The key difference between the two approaches is that Hi-C uses restriction enzymes to digest the DNA while Omni-C uses a DNAase; the two types of digestions should result into very different profiles therefore I cannot use the tools for Hi-C to simulate Omni-C data.

Do you know any useful tools? Any suggestion?

Thanks a lot,

Valentina

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