I wonder wether there are shared TCRB-amino acid sequences in tumor bearing C57Bl/6J mice. We performed an immunoSEQ assay and found no overlap between our mice regarding the TCR repertoire of TILs. Does anyone have made similar observations or know a paper considering this topic?
Thank you in advance.
Hello
See links here may help you
Good Luck
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476240/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832724/
Dear Jens,
if I have understood correctly, your objective is to find lymphocytes with speficic TCR that are expaded in tumor bearing C57Bl/6J mice.
I suggest you 2 paper in which they highlighted many differences in TCR repertoire between Balb/c and tumor bearing Balb-neuT mice after immunization.
Hope this help.
Best
Sergio
https://www.ncbi.nlm.nih.gov/pubmed/17114432
https://www.ncbi.nlm.nih.gov/pubmed/20435927
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