Sorry, I do not find a recent paper on specific immune reaction crusade. One of the immune mechanisms that can modify insulin synthesis from β cell is mediated by CD44 (PLoS ONE 2015), others act on the peripheral resistance as well as those T-cell mediated (Arterioscler Thromb Vasc Biol. 2014). It may be useful "Diabetes at the crossroads: relevance to pathophysiology of disease classification and treatment" only abstract.