Progesterone is an important hormone during pregnancy. It is also used therapeutically to prevent preterm birth at 18-22 weeks. Are there any studies related to prescribing it as a preventative (not therapy) starting at 12-13 weeks. What are some effects of high levels of progesterone in the body.
Progesterone functionally prepares the uterine lining for pregnancy and is also necessary to sustain the pregnancy when it occurs.
Several studies have been conducted on progesterone and prevention of miscarriage. There is controversy as to the effectiveness of progesterone in prevention of miscarriage from different studies. A meta-analysis done in 2013 concluded that there is no evidence to support its use to prevent abortion in women who have had at least three abortions. It can be argued that some factors may be responsible for these findings, For instance; study designs; studies that used already pregnant women are more likely not to establish any effect compared to those that used pre-pregnant women for obvious reasons. Again there are other causes of spontaneous abortion apart from low progesterone, such cases are not likely to respond.
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