I'm interested in sensory deficits in schizophrenia models, and I was wondering whether there are any studies using extracellular or intracellular recordings to investigate cellular responses in sensory cortices. I only know of one study showing that postnatal deletion of NR1 in cortical and hippocampal interneurons results in increased baseline spiking and decreased neural synchrony in S1 pyramidal neurons in actively exploring mice (Belfort et al., 2010). If anyone has some more literature suggestions, I would very much appreciate your feedback.
Belforte, J. E., V. Zsiros, et al. (2010). "Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes." Nat Neurosci 13(1): 76-83.
Yes there is. You'd better read the following and chase the references:
Golembiewski, Jan. (2013). The subcortical confinement hypothesis Cureus, 5(5), e118. doi: 10.7759/cureus.118. Here I propose how the NMDA receptors are linked to tonic/phasic functioning of the D1 and D2 classes of DA neurons.
Golembiewski, Jan. (2012). All common psychotic symptoms can be explained by the theory of ecological perception. Medical Hypotheses, 78, 7-10. doi: 10.1016/j.mehy.2011.09.029. Here I look at perceptual stimulus and tonic vs. phasic neural reactivity. It might not be directly so relevant, but only once decoded another level (as I have done in (2013)
Both of these are available on resaerchgate.net.
Please also see:
Grace, A A, Floresco, S.B., Goto, Y., & Lodge, D.J. (2007). Regulation of firing of dopaminergic neurons and control of goal-directed behaviors. Trends in Neurosciences, 30(5), 220-227. doi: 10.1016/j.tins.2007.03.003. All Grace's work is very relevant.
Schultz, Wolfram, & Dickinson, Anthony. (2000). Neuronal Coding of Prediction Errors. Annual Review of Neuroscience, 23(1), 473-500. doi: 10.1146/annurev.neuro.23.1.473
Best,
Jan
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