While going through some literature I came across chemical signals such as Growth Factors (EGF/ FGF etc) released during wound healing. Are there any more such stimuli one can use to trigger drug release from a polymeric scaffold?
Dear Shaunak Raole
In addition to chemical signals, other factors act in the healing process. Cell types and cytokines regulate each stage of the wound healing response. ECM, extracellular matrix; EGF, epidermal growth factor; FGF, fibroblast growth factor; G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; HA, hyaluronic acid; IL, interleukin; MMP, matrix metalloproteinases; PDGF, platelet-derived growth factor; TGF, transforming growth factor; tPA, tissue plasminogen activator; uPA, urokinase-type plasminogen activator; VEGF, vascular endothelial growth factor.
Article Advancements in the Delivery of Growth Factors and Cytokines...
Article The Role of Macrophages in Acute and Chronic Wound Healing a...
Article Growth Factors For Wound Healing
I hope this helped you.
Regards,
The stimuli required would depend on the biochemical nature of the polymer used. Often, physical parameters such as pH and temperature are often used as stimuli other than biological signals.
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