Hello,
The redox signaling and the activation/nactivation of proteins by specific oxidation is a currently hot topic of research. Nox2 KO mice, resembling the human chronic granulomatous disorder, are available and present some plasticity modifications and mild cognitive decline in addition to the immune problems.
However, I was not able to find any pathways relating LTD and LTP to redox signaling cascades, with elucidation of the envolved pathways etc.
Do you know any work that has been done on this or anyone who is currently working with that?
Thanks for your time!
I know of glutathione as playing an important role in LTP and NMDA receptor modulation
Article Oxidized glutathione modulates N-methyl-D-aspartate- and dep...
Article Redox modulatory site of the NMDA receptor-channel complex: ...
Hi Tiago,
In addition to the papers suggested by Tatyana, I can recommend a quite recent review on this topic:
Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078504/
Hope this helps. Norbert
Tatyana, thanks for the reccomendations, I'll take a look!
Norbert, I had already seen that review, but thanks very much! I had printed it out a while ago but left it and created some kind of fake memory that it was not useful. The review has some really interesting references ( most by Eric Klann's lab anyway), as the oxidative activation of PKC, shown in another paper.
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