We model the physical world, by looking for invariances and laws, then building mathematical models on top of those.

Often we have found that models can be superseded and our picture of the universe changes. Euclidean space, for our universe, was once thought immutable, but then General Relativity came along. Causality was thought to be immutable, but then we discovered spontaneous emission and radioactive decay. Locality was thought to be immutable, but then QM came along. There are now some theories that the speed of light c might change with the age of the universe, and so on.

My question is: is there anything in physics we can be absolutely certain will never change? Or must we ultimately keep an open mind to anything changing?

Are even some of our principles such as Occam's Razor vulnerable to revision?

What is it we actually know that cannot change under any circumstances? Are there any principles or laws that are universal and will always hold at all scales?

I have great difficulty imagining something that's not inviolate, maybe noise and uncertainty at the heart of all physical systems are inviolate. We can never be noise free.

Is there anything else?

Actually maybe that isn't even entirely true that noise is at the heart of everything ...sometimes it isn't there, but only manifests when we make a measurement.

https://www.researchgate.net/publication/256838918

http://www.huffingtonpost.com/derek-abbott/is-mathematics-invented-o_b_3895622.html

Article The Reasonable Ineffectiveness of Mathematics [Point of View]

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