Hi, according to my research experience, there are antigens that can elicit anti IgA production under certain conditions (high TGF-b and IL-6 in the microenvironment). In the context of autoimmunity, there are some examples: there are anti Beta 2 glycoprotein that are IgA and have been shown to be pathogenic. Beta 2 glycoprotein is a serum protein with unknown function, in the antiphospholipid syndrome (part of the Lupus spectrum) tolerance to this protein is loss.
Thank you Renan
In your experience, the antigens that you evaluated only induce IgA antibodies? Did you measure IgG? The antibody response to Beta 2 glycoprotein was only mediated by IgA?. I evaluated the antibody response to an antigen in celiac disease but I only found IgA but not IgG response. I don´t know why I only found IgA response in serum samples.
Theoretically there should be a mixture of antibodies since there will be some degree of class switching anyhow. Do you know that your antigen usually evoke an IgG mediated response? Is the antigen predominantly present in mucusal fluids, if that is the case then increased IgA could be reasonable. Did you check the different subtypes of IgG? It is possible that the antigen do not change the total levels but affect the sub classes. I have experienced this in my samples.
High Heels
I measured the IgG response toward an oral antigen related to wheat, but I did not found any positive patient. I only found an IgA response. As you said, the antigen is present in the mucosal. I did not test for IgG subtypes, this could be a possible solution. Thank you to your answer.
- Badges
- Science topic
- Similar topics
- Biological Science
- Immunology
- Antibodies