A usually overlooked region of a key SARS-CoV-2 protein is an important chink in the virus’s Armour. Neutralizing antibodies against SARS-CoV-2 block particles of the virus, which makes them some of the body’s most potent weapons against the new pathogen. Most of the neutralizing antibodies that researchers have studied target a region of the virus’s spike protein called the receptor-binding domain (RBD). But previous studies have also identified neutralizing antibodies that act against other portions of spike — particularly a region called the N-terminal domain (NTD).
Hamsters treated with one of the strongest NTD-targeting antibodies were protected from SARS-CoV-2 infection.
https://www.nature.com/articles/d41586-020-00502-w
Preprint N-terminal domain antigenic mapping reveals a site of vulner...
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Preprint A potent neutralizing human antibody reveals the N-terminal ...
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