Feynman's parton model (as presented by, for example, W.-Y. P. Hwang, 1992, enclosed) seems to bridge both conceptions, but they do come across as mutually exclusive theories. The S-matrix program, which goes back to Wheeler and Heisenberg (see D. Bombardelli's Lectures on S-matrices and integrability, 2016, enclosed), is promising because - unlike parton theories - it does not make use of perturbation theory or other mathematically flawed procedures (cf. Dirac's criticism of QFT in the latter half of his life).
Needless to say, we do not question the usefulness of the quark hypothesis to classify the zoo of unstable particles (Particle Data Group), nor the massive investment to arrive at the precise measurements involved in the study of high-energy reactions (as synthesized in the Annual Reviews of the Particle Data Group), but the award of the Nobel Prize of Physics to CERN researchers Carlo Rubbia and Simon Van der Meer (1984), or Englert and Higgs (2013), seems to award 'smoking gun physics' only, rather than providing any ontological proof for virtual particles.
To trigger the discussion, we attach our own opinion. For a concise original/eminent opinion on this issue, we refer to Feynman's discussion of high-energy reactions involving kaons (https://www.feynmanlectures.caltech.edu/III_11.html#Ch11-S5), in which Feynman (writing in the early 1960s and much aware of the new law of conservation of strangeness as presented by Gell-Man, Pais and Nishijima) seems to favor a mathematical concept of strangeness or, more to the point, a property of particles rather than an existential/ontological concept. Our own views on the issue are summarized in Preprint Ontology and physics
(see the Annexes for our approach of modeling reactions involving kaons).