Hello, have you looked at Nickolaidis research into carotid plaque? Lucy

Dear Lucy! Thank you for reply! I will find this research.

Nataliia

Hello Lucy,

a lot of Nickolaidis research carotid plaque but no study coronary artery. If you have any links it will be OK.

https://www.ncbi.nlm.nih.gov/pubmed/?term=Nicolaides%20AN%5BAuthor%5D&cauthor=true&cauthor_uid=21663910

In cardiological circles the concept of the vulnerable (unstable) coronary artery plaque has dominated in the last years, more so than in neurology concerning carotid plaques. Definite proof of the concept of the vulnerable plaque is still lacking, however, since the assumed causal relations have not been proven. As far as I know there is no evidence that the atherosclerotic process runs different courses in different large arteries.

Hi Nataliia.. There are some correlation between coronary and carotid plaque.. However plague morphology be be different. One interesting thing is that mixed coronary artery plaque is associated with high risk carotid plaque..

Good result!

Using the determined threshold of 0.09 mL for plaque volumes, this feasibility study suggests that automated 3D ultrasound-based carotid plaque quantification may serve as an important clinical screening tool to help identify patients who are at low risk for significant CAD.

This data confirm correlation between coronary and carotid plaque..

Thank You Sergey for such interesting data.

In this case the threshold 0.09 ml is concerned to plaque volume by 3-D, though in most studies intima-media thickness (IMT) is used as atherosclerotic marker (as a part of carotid vessel with 50% more than nearest intima-media).

Sillesen et al. reported that 3-D plaque burden was highly correlated with coronary calcium and TPA, but not IMT, further, they reported that plaque

burden was as predictive of events as coronary calcium.

Because carotid plaques are focal, and grow along the artery 2.4

times faster than they thicken, and also progress and regress

circumferentially, carotid plaque can change in three dimensions.

IMT changes only in thickness.

http://dx.doi.org/10.1016/j.atherosclerosis.2016.10.045

Measurement of Total Plaque Area (TPA) can also be used.

The advantage of TPA for risk stratification was shown clearly in the Tromso studythe , a population-based study in over 6000 participants, with measurement of IMTand TPA at baseline, and long-term FU. Plaque area strongly predicted risk, but IMT in the CCA did not predict MI or stroke. Progression of IMT does not predict events, whereas progression of TPA is strongly predictive of cardiovascular events: after adjustment for age, sex, BP, cholesterol, smoking, DM, total homocysteine and treatment of BP and cholesterol, patients with plaque progression despite treatment had twice the 5-year risk of stroke, death or myocardial infarction, compared to patients with stable plaque or regression.

E.B. Mathiesen, S.H. Johnsen, T. Wilsgaard, et al., Carotid plaque area and

intima-media thickness in prediction of first-ever ischemic stroke: a 10-year

follow-up of 6584 men and women: the Tromso study, Stroke 42 (2011)

972 e 978

Best regards!

Hi Nataliia,, There is a correlation between extent of coronary artery disease and degree of carotid artery stenosis in patients referred for CAG,.However recent trials are showing that correlation between coronary artery disease and degree of carotid are lesser than previously mentioned trials.. This trial published in JACC might help you.. Thanks

Thank You Biswajit! Very interesting rsearch!

Best regards!