I have met practitioners who consider uMT-/- mice uni-laterally as B cell deficient. The impression of reliable conclusion is created that HSCs in such mice do not/cannot differentiate into the B lymphoid lineage. That "leakage" occurs in BALB/c, but not in C57BL/6, casts doubt on this inference. In your opinion, how would you interpret the strain-discrepancy in the context of hematopoiesis? I have formed an opinion of my own coming from the stem cell field, yet I would like to know the thoughts of immunologists, genome specialists and others.
This question derived from a question asked by Wingender and the answers given: Are there any mature B cells remaining in the uMT-/- B cell deficient mice? - ResearchGate. Available from: https://www.researchgate.net/post/Are_there_any_mature_B_cells_remaining_in_the_uMT--B_cell_deficient_mice#57cf2bf3eeae391dd4245d51 [accessed Sep 6, 2016].
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