Are DRM (detergent resistance membrane) are the same as Raft? What is the difference between them? Can we call DRM the same as Lipid raft?
Thank you so much, I have read these article before but I did not find out what exactly make difference between them.
Dear Vahideh,
They are the same. There is no difference.
Please read the following paragraphs:
The plasma membranes of cells contain combinations of glycosphingolipids and protein receptors organized in glycolipoprotein microdomains termed lipid rafts.[1][2][3] These specialized membrane microdomains compartmentalize cellular processes by serving as organizing centers for the assembly of signaling molecules, influencing membrane fluidity and membrane protein trafficking, and regulating neurotransmission and receptor trafficking.[3][4] Lipid rafts are more ordered and tightly packed than the surrounding bilayer, but float freely in the membrane bilayer.[5] Although more common in plasma membrane, lipid rafts have also been reported in other parts of the cell, such as Golgi and lysosomes.
Because of their composition and detergent resistance, lipid rafts are also called detergent-insoluble glycolipid-enriched complexes (GEMs) or DIGs[9] or Detergent Resistant Membranes (DRMs). However the validity of the detergent resistance methodology of membranes has recently been called into question due to ambiguities in the lipids and proteins recovered and the observation that they can also cause solid areas to form where there were none previously.[10]
1-Thomas, Sunil; Preda-Pais, Anca; Casares, Sofia; Brumeanu, Teodor-D (2004). "Analysis of lipid rafts in T cells". Molecular Immunology 41 (4): 399–409. doi:10.1016/j.molimm.2004.03.022. PMID 15163537.
2-Thomas, Sunil; Kumar S., Rajeev; Brumeanu, Teodor−D. (2004). "Role of lipid rafts in T cells". Archivum Immunologiae et Therapiae Experimentalis 52 (4): 215–24. PMID 15467486.
3- a b c Korade, Zeljka; Kenworthy, Anne K. (2008). "Lipid rafts, cholesterol, and the brain". Neuropharmacology 55 (8): 1265–73. doi:10.1016/j.neuropharm.2008.02.019. PMC 2638588. PMID 18402986.
10-Heerklotz, H. (2002). "Triton Promotes Domain Formation in Lipid Raft Mixtures". Biophysical Journal 83 (5): 2693–701. Bibcode:2002BpJ....83.2693H. doi:10.1016/S0006-3495(02)75278-8. PMC 1302353. PMID 12414701.
Hoping this will be helpful,
Rafik
Hello Rafik, thanks for your reply, i agree with you . I think these two name must be define more precisly which let us to use them properly. there is a huge confugation between these two therm.
Thank you so much Mr Surma. your reply was prety clear and enlightened me.
so thank to you . I think I need be agree with you.
cheers
vahideh
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