http://cshperspectives.cshlp.org/site/misc/mitochondria.xhtml here you will find the special issue of Cold Spring Harbor Perspectives about Mitochondria. There is a review about mitochondria dynamics also available there. I think this is most up to date and general. There is also a good general review paper from Nature Reviews but it is from 2010 therefore not really up to date.

Best

Tomasz

Hello Rostyslav,

here are some links to nice reviews on the topic:

Friedman JR, Nunnari J.

Mitochondrial form and function.

Nature. 2014 505(7483):335-43.

http://www.ncbi.nlm.nih.gov/pubmed/24429632

and

Chan DC.

Fusion and fission: interlinked processes critical for mitochondrial health.

Annu Rev Genet. 2012;46:265-87.

http://www.ncbi.nlm.nih.gov/pubmed/22934639

Best regards

Here you have two papers I wish they will help you

The mitochondria-targeted anti-oxidant MitoQ reduces aspects of mitochondrial fission in the 6-OHDA cell model of Parkinson's disease.

Solesio ME, Prime TA, Logan A, Murphy MP, Del Mar Arroyo-Jimenez M, Jordán J, Galindo MF.

Biochim Biophys Acta. 2013 Jan;1832(1):174-82. doi: 10.1016/j.bbadis.2012.07.009.

3-Nitropropionic acid induces autophagy by forming mitochondrial permeability transition pores rather than activating the mitochondrial fission pathway.

Solesio ME, Saez-Atienzar S, Jordan J, Galindo MF.

Br J Pharmacol. 2013 Jan;168(1):63-75. doi: 10.1111/j.1476-5381.2012.01994.x.

Kind regards

Francisco

Thank you everyone for your help! Lost of good links which led me to a further question: how is the mitochondrial network reorganized during the cell cycle? During cell cycle arrest and mitosis? In healthy and cancer cells? How does the cytoskeletal machinery responds? Sorry for the many questions, just curious about how fission/fusion is linked with the cell cycle and transportation of mitochondria. Thanx in advance!

Hello Rostyslav,

I just came across an interesting publication on the role of mitochondrial dynamics on cell cycle progression in cancer cells:

http://www.ncbi.nlm.nih.gov/pubmed/24632851

The authors conclude that inhibiting mitochondrial fission might be a vital therapeutic strategy for the inhibition of cancer cell proliferation.

With best regards!

Hi Rostyslav,

Check this "New England Journal of Medicine" review on mito dynamics and human diseases. Cancer is there of course :)

http://www.nejm.org/doi/full/10.1056/NEJMra1215233

Good luck

Thanks Haitham - this, focused on diseases, review looks interesting.

> How does the cytoskeletal machinery respond?

A review that addresses the role of actin filaments in mitochondrial plasticity:

http://dx.doi.org/10.1016/j.ceb.2013.09.002

The connection of mitochondria to actin filaments is important for targeting them to specific locations in the cell and also for the controlled division of these organelles.

Big thank you to everyone! I really appreciate your help. If you find any interesting info regarding this topic, please let me know. Thanks in advance