Trying to do an Ullmann-type reaction to form a diaryl ether between: aryl bromide containing an aminothiazole group and 4-chlorophenol. The reaction usually involves a Cu(I) source and some ligand to accelerate the reaction. I have tried amino-acid and phenanthroline as ligands but the reaction showed no progress (by TLC). I have tried microwave-assisted at very high temperature and this has not worked either.
I was wondering if anyone else had difficulty doing an Ullmann-type reaction to form a ether linkage and overcame this?
DMEDA and other diamines would be good choices for you. Remember that the base plays a very important rule in these reactions. There are nice papers and reviews disclosed by Buchwald’s research group.
Dear Sir;
I think this a ref. is very important for your question.
Good luck
- Sun, Xu et al. Angewandte Chemie, International Edition, 55(5), 1704-1709; 2016
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