The research that we are performing is using 2-times cortisol (8 AM - 10 PM) as circadian biomarker for acute sleep deprivation. The thing is, we ask them to avoid the ingestion of any caffeine-based substances (beverages or medications) the day before the test, but we want to know if the caffeine ingestion can anyhow "reset", or modify the cortisol curve after the first sample collected. Does anyone knows if there are any papers assessing the effects of caffeine over the cortisol circadian curve?
Caffeine blocks adenosine receptors. I don't' think it has much effect on circadian rhythm, but if someone is using it in excess, it could possibly delay the circadian rhythm behaviorally.
I also have this insight about the caffeine role on circadian rhythm from other papers we published in our lab. All of our research showed normal cortisol-based circadian rhythm in control population without a caffeine restriction. But none of those use a sleep deprivation protocol, and that is the reason I'm looking into some other references. I may be overthinking things, but there may be a chance that these behavioral patterns reflects the cortisol-based circadian rhythm of our sample. Thank you for your answer.
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