Actually I am working with genome based metabolic network reconstruction. But I didn't get any success yet in using a software which can be handy to work with and if someone have used it before in their work please do mention while responding.
Cytoscape is the best with useful plugins for GSMr but there are plenty of databases and tools
http://metexplore.toulouse.inra.fr
MIRAGE (MetabolIc Reconstruction via functionAl GEnomics)
http://www.cs.technion.ac.il/~tomersh/methods.html
Dear
I could add also these
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361743/
http://brg.ai.sri.com/ptools/
https://omictools.com/metabolic-network-analysis-category
https://www.ncbi.nlm.nih.gov/pubmed/25267793
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