Thanks Prof will check

Before all these linkage analysis studies emerged, the very starting of genetic predisposition studies started as twin studies and family aggregation studies. When it was found over and over again that periodontal disease was seen in families and that a family history of periodontitis (specially aggressive) was a major risk factor, then came an era of reared apart and reared together twin studies (mono and dizygotic) to verify that the effect was not just environmental but had a genetic link to it.

After getting positive results from those studies, then the search began for the specific genetic polymorphism and eventually genetic linkage analysis studies and so called SNP studies started. Now the new buzz is multi-linkage analysis studies. That means a combination of different SNP's would be having effect and not just one or two.

You will find tHe answer to your question in articles published between 70's to 90's

1- Periodontal status among relatives of aggressive periodontitis patients and reliability of family history report  -M. A. Llorente andG. S. Griffiths

http://onlinelibrary.wiley.com/doi/10.1111/j.1600-051X.2005.00887.x/abstract?deniedAccessCustomisedMessage=&userIsAuthenticated=false

2- Genetic and environmental risk factors for chronic periodontitis and aggressive periodontitis

Ayala Stabholz, W. Aubrey Soskolne andLior Shapira

http://www.ncbi.nlm.nih.gov/pubmed/20403110

offcourse

1)rapid loss of attachment

2)systemically healthy

and 3)familial aggregation are definition criteria for AgP

my question was not that

Prof Tatakis link answers the question...if there are two AgP patients, one with family history  of AgP and other without family history of AgP..risk of periodontal destruction is more in the patient with family history of AgP..

thanks

SR

Oh Ok.

Sorry

Dear Ramachandra SS

This may not directly answer your question, but it is perhaps pertinent.

The following study looked at risk indicators for periodontitis (chronic and aggressive combined) and showed that risk for periodontitis was greater among subjects who reported positive family history.

Ababneh KT, Abu Hwaij ZM, Khader YS. Prevalence and risk indicators of

gingivitis and periodontitis in a multi-centre study in North Jordan: a cross

sectional study. BMC Oral Health. 2012 Jan 3;12:1. doi: 10.1186/1472-6831-12-1.

PubMed PMID: 22214223

Any published literature wherein cases of aggressive periodontitis with positive family history are at more risk for increased periodontal breakdown? - ResearchGate. Available from: https://www.researchgate.net/post/Any_published_literature_wherein_cases_of_aggressive_periodontitis_with_positive_family_history_are_at_more_risk_for_increased_periodontal_breakdown [accessed Apr 23, 2016].

http://www.ncbi.nlm.nih.gov/pubmed/20403110