Any ideas about interplay between Shh pathway and expression of Hox genes?

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Gregory Dressler

There is a nice article in Dec 14 Science on Hox gene mutaitons and Gli mutations on digit patterning. I have never seen such polydactyly.

Billie Moore

I should be more current on this issue but I am sadly not. What portion of the foregut are you referring to? In the pharyngeal region of the Shh mutant, expression of Hoxa2 and Hoxa3 genes was normal. I recall Hoxb1 was normal as well just slightly faint and difficult to determine if it was due to atrophy or not.

What are you looking for in particular?