Anti-IL-2 RA use in liver transplantation has been suggested to be beneficial in preventing HCC recurrence after liver transplantation (Toso et al: Hepatology 2010, 51:1237). This agent has also been utilized in cancer therapy by targeting T regs cells to improve responses to immunotherapy. I have suspected that use of these agents has a much longer immunological consequence than currently appreciated. What evidence (inducing protocols) exists that this has implications in tolerance?
the anti CD25 (zenapax and daclizumab) are commonly used also in the induction protocols for islet transplantation. In addition to the effect on Treg we found that blocking CD25-gamma chain interaction makes more gamma-chain available for other gamma-chain receptors. An important one is IL-7. the immunological effect is an increase of T cell sensitivity to IL-7 and consequently more homeostatic proliferation. (monti p et al Am J tranpl 2009; 9: 2727-2735 and monti p et at J Clin Invest 2008; 118: 1806-1814)
Thank you - this makes sense and may explain why we concluded that the higher incidence of GVHD after liver transplant appeared to be correlated with the use of Simulect. Given that memory T cells appear to reconstitute faster in the homeostatic proliferative environment, this may explain this finding. The fact that we have not seen a single case after stopping simulect induction further supports the correlation.
- Badges
- Science topic
- Similar topics
- Biological Science
- Anatomy
- Tissue