Everything is good in moderation. Too much is too much.

@Sadoon

Rather than focusing on direct supplementation with external antioxidants, a more sustainable and perhaps safer approach might involve enhancing the body's natural antioxidant defenses.

This includes promoting the activity of endogenous antioxidant enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase. These enzymes play a critical role in protecting cells from oxidative damage and are tightly regulated by the body, allowing for a more controlled response to oxidative stress.

@Sadoon

The idea of "fighting free radicals" as a therapeutic strategy might not always be the best approach, especially when antioxidants are taken in excessive amounts.

Ultimately, we may need to move away from the idea of indiscriminately "fighting free radicals" and toward promoting a balanced and adaptable oxidative state.

Yurii V Geletii

Dear Dr .

I agree that moderation is key to benefiting from any nutritional element. However, are there specific studies that define the threshold between benefit and harm when consuming antioxidants? Also, do you think that certain types of antioxidants (natural vs. synthetic) pose different risks when overused? It would be valuable to hear your thoughts on this!

Rich C Joseph

Dear Dr Rich C Joseph,

Thank you for your insightful views. I completely agree that enhancing the body's natural defenses and maintaining an oxidative balance is more effective than excessively "fighting free radicals." In this regard, what strategies or dietary models do you consider capable of supporting this dynamic balance? And how can we integrate these mechanisms to achieve effective adaptation to environmental challenges?

I look forward to hearing your innovative insights.

@ Dr Sadoon Mohammed

To support the body’s natural defenses, we can focus on eating antioxidant-rich foods like fruits (berries, citrus), vegetables (spinach, broccoli), and nuts (almonds, walnuts). Include healthy fats such as omega-3s found in fish and flaxseeds, and limit processed foods. Lifestyle strategies like; Regular physical activity, getting enough sleep, and managing stress also help the body cope with oxidative stress.

Also, to adapt to environmental challenges, staying hydrated, avoiding smoking and excessive alcohol, and eating foods rich in vitamins (like C, E, and A) and minerals (such as zinc and selenium) can boost the immune system and reduce the effects of toxins.

I hope you find this helpful

There are thousands of publications on effects of antioxidant consumption. I believe that everything is good in moderation. Too much is too much.